BioPure’s CzagaTM (pronounced ‘chaga’) is made from the fungus Inonotus obliquus. This mushroom grows as an irregularly formed mass of mycelium, resembling burnt charcoal, on the bark of birch trees in Siberia, Russia, eastern Europe, and some parts of the United States and Canada. Chaga has been revered as a medicinal substance for centuries. The most common way it was used traditionally was to boil it and create an aqueous extract. It was considered a cleansing substance and was used internally and externally to keep people healthy.* It was also commonly used for supporting cardiovascular and gastrointestinal health.*
Chaga mushrooms have been found to have a wide variety of biologically active compounds and secondary metabolites including triterpenoids such as inotodiol, lanosterol, and betulinic acid; sterols such as ergosterol; melanins, phenolic compounds, polysaccharides, vitamins, proteins, and more.
Numerous studies have been carried out with Chaga extracts and components. The melanin complex of Chaga may be helpful in supporting healthy DNA.* Cognitive functions such as learning and memory in mice were enhanced in response to administration of an extract of Chaga.* Chaga’s polysaccharides have been found to support the immune system and have significant antioxidant activity.*
Free-radical reactions at the cellular level have been thought to affect the processes of aging and other undesirable health effects. Chaga has been investigated in numerous studies for its antioxidant capabilities.* Hot water extract of Chaga mushroom was also studied for its impact on colon health.* The fact that Chaga produced little or no toxicity in any of its experiments makes it well-deserving of further study for its potential health benefits.
BioPure’s CzagaTM is a freeze-dried extract of 100 percent organic wild Inonotus obliquus and is not produced from cultivated sources. It is sustainably harvested from fungi growing on wild live birch trees in severe northern climates. This maximizes the availability and potency of the beneficial bioactive ingredients. BioPure’s Czaga™ imparts a delicious vanilla flavor to your beverage. People even use it in place of coffee for its energizing effects.
Bisko, NA, Mitropolskaya NY, Ikonnikova NV. Melanin Complex from Medicinal Mushroom Inonotus obliquus (Pers.: Fr.) Pilat (Chaga) (Aphyllophoromycetideae). Int J Med Mushrooms. 2002, Vol 4, Issue 2.
Cui Y, Kim DS, Park KC. Antioxidant effect of Inonotus obliquus. J Ethnopharmacol. 2005 Jan 4;96(1-2):79-85.
Fulda S. Betulinic Acid for Cancer Treatment and Prevention. Int J Mol Sci. 2008 June; 9(6): 1096–1107.
Gemma C, Vila J, Bachstetter A, Bickford PC. Oxidative Stress and the Aging Brain: From Theory to Prevention. Chapter 15. In: Brain Aging – Models, Methods, and Mechanics. Edited by David R Riddle. CRC Press 2007.
Giridharan VV, Thandavarayan RA, Konishi T. Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus – a medicinal mushroom. Food Funct. 2011 Jun;2(6):320-7.
Kim YO, Han SB, Lee HW, Ahn HJ, Yoon YD, Jung JK, Kim HM, Shin CS. Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci. 2005 Sep 23;77(19):2438-56.
Lee SH, Hwang HS, Yun JW. Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT-29 human colon cancer cells. Phytotherapy Research. Volume 23, Issue 12, pages 1784–1789, December 2009.
Lemieszek MK, Langner E, Kaczor J, Kandefer-Szerszeń M, Sanecka B, Mazurkiewicz W, Rzeski W. Anticancer effects of fraction isolated from fruiting bodies of Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae): in vitro studies. Int J Med Mushrooms. 2011;13(2):131-43.
Mu H, Zhang A, Zhang W, Cui G, Wang S, and Duan J. Antioxidative Properties of Crude Polysaccharides from Inonotus obliquus. Int. J. Mol. Sci. 2012, 13, 9194-9206.
Mullauer FB, Kessler JH, Medema JP. Betulinic acid, a natural compound with potent anticancer effects. Anticancer Drugs. 2010 Mar;21(3):215-27.
Najafzadeh M, Reynolds PD, Baumgartner A, Jerwood D, Anderson D. Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of patients with inflammatory bowel disease. Biofactors. 2007;31(3-4):191-200.
Nomura M, Takahashi T, Uesugi A, Tanaka R, Kobayashi S. Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. Anticancer Res. 2008 Sep-Oct;28(5A):2691-6.
Pan HH, Yu XT, Li T, Wu HL, Jiao CW, Cai MH, Li XM, Xie YZ, Wang Y, Peng T. Aqueous extract from a Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), prevents herpes simplex virus entry through inhibition of viral-induced membrane fusion. Int J Med Mushrooms. 2013;15(1):29-38.
Sun JE, Ao ZH, Lu ZM, Xu HY, Zhang XM, Dou WF, Xu ZH. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol. 2008 Jun 19;118(1):7-13.
Won DP, Lee JS, Kwon DS, Lee KE, Shin WC, Hong EK. Immunostimulating activity by polysaccharides isolated from fruiting body of Inonotus obliquus. Molecules and Cells. February 2011, Volume 31, Issue 2, pp 165-173.
Zheng W, Miao K, Liu Y, Zhao Y, Zhang M, Pan S, Dai Y. Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production. Appl Microbiol Biotechnol. 2010 Jul;87(4):1237-54.
Zheng W, Zhang M, Zhao Y, Miao K, Pan S, Cao F, Dai Y. Analysis of antioxidant metabolites by solvent extraction from sclerotia of Inonotus obliquus (Chaga). Phytochem Anal. 2011 Mar-Apr;22(2):95-102.