BioPure’s Core-STM is a modified formulation of our CoreTM product. Core-STM is a blend of highly bioavailable forms of 6 minerals, 4 vitamins, 1 amino acid, and an herb, in a unique combination formulated to support core aspects of human health.*
With the exception of calcium, which forms a major part of our bone structure, most of the minerals in the human body are present in relatively small amounts, but their importance to human health cannot be overstated.* The trace minerals in Core-STM play critical roles as cofactors in a myriad of enzymatic pathways.* Although most minerals are available in foods we eat, deficiencies can occur from a number of causes including environmental factors, injury recovery, genetics, stress, medications, overexertion, athletes demanding high performance, aging, diets, bacterial infections, and lifestyle differences. Core-STM is an additional source of important trace minerals and other nutrients.[sidereadmore]
In Core-STM, we have removed supplemental manganese from the formula for consumers who may prefer this formulation based on their consultation with their health care provider. It is important to understand that manganese is an essential trace mineral that plays critical roles in the skeletal, circulatory, reproductive, and nervous systems, and numerous enzymatic, immune, and antioxidant reactions throughout the body.* Even though most people receive sufficient amounts from the food they eat (especially manganese-rich foods such as pineapple, pecans, peanuts, oats, wheat, and beans), we suggest consulting your healthcare practitioner to be sure you are receiving an adequate supply of manganese in your diet.
Core-STM is comprised of the following for 2 capsules:
Vitamin A (700 IU): Vitamin A comprises a group of fat-soluble retinoids especially important for eyesight, reproduction, immune function, skin health, and cellular transport reactions.*
Vitamin B6, in the form of Pyridoxine HCl (20 mg) and Pyridoxine 5-Phosphate (33.5 mg): These compounds are source ingredients of bioactive vitamin B6, readily available to participate as a cofactor in nearly 100 enzymatic reactions within the human body.* One of eight water-soluble vitamins in the B complex, vitamin B6 is critical in the production of amino acids, in obtaining energy from the food we eat, and in supporting heart health.*
Biotin (3,000 mcg): Biotin is a member of the B complex and is sometimes referred to as Vitamin H. It is an essential micronutrient for all mammals. As a coenzyme, Biotin plays key roles in the breakdown of fats, carbohydrates, and proteins.* It supports skin, hair, and nail health, normal blood sugar metabolism, and proper neurological function, and is particularly important during pregnancy for proper fetal development.*
Niacin (20 mg): Also referred to as vitamin B3, niacin is another one of the 8 vitamins in the B complex. Niacin is perhaps best known for its support in helping to maintain cholesterol levels that are already within the normal range.* Like vitamin B6, niacin is also involved in the production of energy from the foods we eat.* Niacin also helps the adrenal gland make sex and stress-related hormones.*
Magnesium (100 mg): Magnesium is one of the most plentiful minerals in the human body, playing key roles in hundreds of enzymatic reactions and metabolic functions.* It helps regulate cell membrane transport, supports healthy bones and teeth, facilitates muscle contraction, supports cardiovascular health, aids in energy production, is part of DNA and RNA synthesis, and more.* Chelated to the amino acid glycine, magnesium bisglycinate in Core-S provides the highest level of absorption, bioavailability, and safety. The chelated form also creates a buffering effect and may reduce potential laxative side-effects.*
Zinc, as PepZin GI® Carnosine (28.5 mg): Zinc is an essential trace mineral, and is ubiquitous within cells throughout the body. Its numerous roles in human metabolism include catalytic, structural, and regulatory functions.* Zinc supports the immune system, eyesight, neurological function, and growth and development at all ages–especially prenatally and during infancy.* Core-S provides zinc in a combined form with the protein-building block carnosine, giving it added value for gastric health.* The compound supports maintenance of a healthy mucosal lining in the gut.*
Chromium (125 mcg): Chromium is involved with thryroid metabolism.* It is also involved in RNA synthesis and protein metabolism.* The chromium in Core-S is chemically bound with a form of niacin, known as nicotinate, and the amino acid glycine. Chromium nicotinate glycinate is safe and highly bioavailable.
Molybdenum (50 mcg): Molybdenum is needed in the human body in small amounts to form compounds with organic molecules and enzymes that affect numerous processes including protein synthesis, iron uptake, detoxification, and elimination of wastes.* Some people use molybdenum to help support the immune system and dental health.* In Core-S, molybdenum is bound to the amino acid glycine, facilitating its absorption and bioavailablity.
Boron as citrate chelate (750 mcg): Although not yet considered essential, there is growing evidence of the importance of this trace mineral. Boron is involved in many bodily functions including the metabolism of calcium, magnesium, and vitamin D, supporting healthy bone growth and joint movement, and in the regulation of thyroid and sex hormones.*
L-Taurine (50 mg): Taurine is an amino acid that is important for cardiovascular health and as an antioxidant.* Taurine also supports a healthy digestive system and retinal development and function.*
Lithium (3 mg): Lithium is a metal that is found within many minerals. In the orotate chelate compound, it is available to the human body in a safe, low-dose, highly absorbable form. Lithium affects the flow of sodium through our muscle and nerve cells.* It supports vitamin B12 and folate metabolism, has antioxidant properties, and may help with the nervous system and mood.*
Horsetail (2 mg): The herb horsetail (Equisetum arvense) has been used in herbal medicine since ancient Roman and Greek times. It is especially known for its diuretic effects and may be helpful in supporting kidney and bladder health.* In addition, it has shown antioxidant properties and beneficial effects on mood.*
Other ingredients present in small amounts are silica, cellulose, and ascorbyl palmitate. Silica, also known as silicon dioxide, is a naturally occurring substance that the human body needs a very small amount of for healthy bones, collagen, and cartilage.* In Core-STM, silica serves the dual purpose of acting as a flow agent in supplements. The capsules are made with a small amount of non-digestible cellulose, providing a vegetarian alternative to animal-sourced gelatin capsules. Ascorbyl palmitate is a fat-soluble antioxidant that contributes an insignificant amount of Vitamin C, and primarily serves the purpose of protecting and extending the shelf-life of all the fat-soluble antioxidants in the supplement.
Aguirre JD1, Clark HM, McIlvin M, Vazquez C, Palmere SL, Grab DJ, Seshu J, Hart PJ, Saito M, Culotta VC. A manganese-rich environment supports superoxide dismutase activity in a Lyme disease pathogen, Borrelia burgdorferi. J Biol Chem. 2013 Mar 22;288(12):8468-78.
Aschner JL and Aschner M. Nutritional aspects of manganese homeostasis. Molecular Aspects of Medicine 26 (2005) 353–362.
Bahmani M, Rafieian-Kopaei M, Saki K, Majlesi M, Bahmani F, Bahmani F, Sharifi A, Rasouli S, Sepahvand R, Abdollahi R, Moghimi-Monfared O and Baharvand S. Identification of medical plants acting on reproductive system disorders: An ethnobotanical study in Urmia, Northwest of Iran. Journal of Chemical and Pharmaceutical Research, 2015, 7(2):493-502.
Cefalu WT and Hu FB. Role of Chromium in Human Health and in Diabetes. Diabetes Care. November 2004 vol. 27 no. 11 2741-2751.
Cipriani A, Hawton K, Stockton S, Geddes JR. Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis. BMJ June 2013, pp 1-13.
Coughlan MP. The role of molybdenum in human biology. Journal of Inherited Metabolic Disease 1983, Volume 6, Issue 1 Supplement, pp 70-77.
Dinca L and Scorei R. Boron in Human Nutrition and its Regulations Use. Journal of Nutritional Therapeutics, 2013, 2, 22-29.
English J. Magnesium Stearate: A Safe and Effective Filler – Setting the Record Straight. An Interview with Dr. Dana Myatt, NMD. Digestion, Immune System 2013 Nov 6.
Huskisson E, Maggini S, and Ruf M. The Role of Vitamins and Minerals in Energy Metabolism and Well-Being. The Journal of International Medical Research 2007; 35: 277-289.
Krejpcio Z. Essentiality of Chromium for Human Nutrition and Health. Polish Journal of Environmental Studies Vol. 10, No. 6 (2001), 399-404.
Lamson D and Plaza S. The Safety and Efficacy of High-Dose Chromium. Alternative Medicine Review. Vol 7 No 3; 2002. Pg 218-235.
Lourenço R, Camilo ME. Taurine: a conditionally essential amino acid in humans? An overview in health and disease. Nutr Hosp. 2002 Nov-Dec;17(6):262-70.
Mahmood A, FitzGerald AJ, Marchbank T, Ntatsaki E, Murray D, Ghosh S, and Playford RJ. Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes. Gut. 2007 Feb; 56(2): 168–175.
Marshall, TM. Lithium as a Nitrient. Journal of American Physicians and Surgeons. Winter 2015 Volume 20:No. 4, pp 104-109.
Martin KR. The chemistry of silica and its potential health benefits. J Nutr Health Aging. 2007 Mar-Apr;11(2):94-7.
Miroff G, Mowles R, Pangborn JB, Philpott WH, Molybdenum for Candida albicans Patients and Other Problems. The Digest of Chiropractic Economics Jan-Feb 1991, 31:4 pp 56-63.
Mock DM. Adequate Intake of Biotin in Pregnancy: Why Bother? J Nutr. 2014 Dec; 144(12): 1885-1886.
Newnham RE. Essentiality of boron for healthy bones and joints. Environ Health Perspect. 1994 Nov;102 Suppl 7:83-5.
Nielsen FH and Meacham SL. Growing Evidence for Human Health Benefits of Boron. Journal of Evidence-Based Complementary & Alternative Medicine. October 2011 vol. 16 no. 3 169-180.
Pokorski M1, Marczak M, Dymecka A, Suchocki P. Ascorbyl palmitate as a carrier of ascorbate into neural tissues. J Biomed Sci. 2003 Mar-Apr;10(2):193-8.
Posey JE, Gherardini FC. Lack of a role for iron in the Lyme disease pathogen. Science. 2000 Jun 2;288(5471):1651-3.
Prasad AS. Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease. Adv. Nutr. 4: 176–190, 2013.
Rodriguez MR. Importance of biotin metabolism. Rev Invest Clin. 2000 Mar-Apr;52(2):194-9.
Roohani N, Hurrell R, Kelishadi R, Schulin R. J Res Med Sci. 2013 Feb; 18(2): 144-157.
Said HM. Biotin: the forgotten vitamin. Am J Clin Nutr. February 2002 vol. 75 no. 2 179-180.
Seibrecht S. Magnesium Bisglycinate as safe form for mineral supplementation in human nutrition. OM & Ernährung 2013 Nr. 144. 16 pages.
Shobha H. Ganji, Vaijinath S. Kamanna, Moti L. Kashyap. Niacin and cholesterol: role in cardiovascular disease (review). Journal of Nutritional Biochemistry. June 2003 Volume 14, Issue 6, Pages 298–305.
Skaar EP. The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts. PLoS Pathog. 2010 Aug; 6(8).
Soetan KO, Olaiya CO and Oyewole OE. The importance of mineral elements for humans, domestic animals and plants: A review. African Journal of Food Science Vol. 4(5) pp. 200-222, May 2010.
Suidasari S, Hasegawa T, Yanaka N and Kato N. Dietary supplemental vitamin B6 increases carnosine and anserine concentrations in the heart of rats. Springerplus, 2015 Jun 19;4:290.
Xu YJ, Arneja AS, Tappia PS, and Dhalla NS. The potential health benefits of taurine in cardiovascular disease. Exp Clin Cardiol. 2008 Summer Vol 13(2):57-65.