Broccoli (Brassica oleracea), is a member of the cabbage family (Brassicaceae), also referred to as cruciferous (“cross-bearing”) vegetables, because of the four-petaled shape of their flowers. The coaching most of us received as children to eat our broccoli was for good reason as it contains vitamins, minerals, and fiber, and is an excellent source of beneficial bioactive phytonutrients.
Among the beneficial phytonutrients found in some strains of broccoli, is a substance called glucoraphanin. The sprouting seeds of broccoli store a concentrated amount of this nutrient, to supply the growing plant. When the sprouts undergo mechanical stimulation, such as chopping or chewing, glucoraphanin comes in contact with the enzyme myrosinase, and hydrolyzes to a potent isothiocyanate compound referred to as sulforaphane. Sulforaphane is the subject of hundreds of scientific studies and has demonstrated numerous properties beneficial to human health. Of particular interest is sulforaphane’s ability to activate proteins that regulate antioxidant responses. Broccoli sulforaphane induces production of certain enzymes involved in antioxidation and have been shown to interfere with some viruses being able to insert genetic material into host chromosomes. Sulforaphane also showed the potential to help the body maintain healthy blood sugar levels, support cardiovascular health, provide neuroprotective effects, encourage detoxification of toxic airborne pollutants, and exert a unique mode of viral defense.
Just one quarter teaspoon of BioPure’s Broccoli Sprout Powder dissolved in a glass of water or juice, is a convenient and easy-to-use way of getting a daily dose of these beneficial plant nutrients. When taking any nutritional supplement, we recommend the oversight of a licensed healthcare provider to monitor any sensitivities or interactions with other products being used. Occasionally, a patient will take too much Broccoli Sprout Powder and experience some stomach upset. If this occurs, the dose should be lowered, or stop taking the product altogether.
Cramer JM, Jeffery EH. Sulforaphane absorption and excretion following ingestion of a semi-purified broccoli powder rich in glucoraphanin and broccoli sprouts in healthy men. Nutr Cancer. 2011;63(2):196-201.
Furuya AKM, Sharifi HJ, Jellinger RM, Cristofano P, Shi B, de Noronha CMC. Sulforaphane Inhibits HIV Infection of Macrophages through Nrf2. PLoS Pathog. 2016; 12(4): e1005581.
Haristoy X, Angioi-Duprez K, Duprez A, and Lozniewski A. Efficacy of Sulforaphane in Eradicating Helicobacter pylori in Human Gastric Xenografts Implanted in Nude Mice. Antimicrobial Agents & Chemotherapy, Dec. 2003, p.3982–3984.
James D, Devaraj S, Bellur P, Lakkanna S, Vicini J, Boddupalli S. Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. Nutr Rev. 2012 Nov;70(11):654-65.
Kim HV, Kim HY, Ehrlich HY, Choi SY, Kim DJ, Kim YS. Amelioration of Alzheimer’s disease by neuroprotective effect of sulforaphane in animal model. The Journal of Protein Folding Disorders. 2013. Volume 20. Issue 1.
Kim JK and Park SU. Current Potential Health Benefits of Sulforaphane. EXCLI Journal 2016;15:571-577.
Murashima M, Watanabe S, Zhuo X-G, Uehara M, Kurashige A. Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one‐week intake of broccoli sprouts. Biofactors. 2004;22(1-4):271-5.
Noah TL, Zhang H, Zhou H, Glista-Baker E, Müller L, et al. Effect of Broccoli Sprouts on Nasal Response to Live Attenuated Influenza Virus in Smokers: A Randomized, Double-Blind Study. (2014) PLoS ONE 9(6): e98671.
Singh K, Connors SL, Macklin EA, Smith KD, Fahey JW, Talalay P, and Zimmerman AW. Sulforaphane treatment of autism spectrum disorder (ASD). Proceedings of the National Academy of Sciences, Oct 2014, 111 (43) 15550-15555.
Suppipat K, Park CS, Shen Y, Zhu X, Lacorazza HD. Sulforaphane Induces Cell Cycle Arrest and Apoptosis in Acute Lymphoblastic Leukemia Cells. PLoS One. 2012; v7(12).
Tang L, Zirpoli GR, Guru K, et al. Intake of cruciferous vegetables modifies bladder cancer survival. Cancer Epidemiol Biomarkers Prev. 2010;19(7):1806-1811.
Wu CC, Chuang HY, Lin CY, Chen YJ, Tsai WH, Fang CY, Huang SY, Chuang FY, Lin SF, Chang Y, Chen JY. Inhibition of epstein‐barr virus reactivation in nasopharyngeal carcinoma cells by dietary sulforaphane. Molecular Carcinogenesis. Volume 52, Issue 12: December 2013. Pages 946-958.
Yu J-S, Chen W-C, Tseng C-K, Lin C-K, Hsu Y-C, Chen Y-H, et al. (2016) Sulforaphane Suppresses Hepatitis C Virus Replication by Up- Regulating Heme Oxygenase-1 Expression through PI3K/Nrf2 Pathway. PLoS ONE 11(3): e0152236.
Zhang R, Miao Q-W, Zhu C-X, Zhao Y, Liu L, Yang J, and An L. Sulforaphane Ameliorates Neurobehavioral Deficits and Protects the Brain From Amyloid β Deposits and Peroxidation in Mice With Alzheimer-Like Lesions. American Journal of Alzheimer’s Disease & Other Dementias, July 13, 2014. Vol 30, Issue 2, pp. 183 – 191.