Bravo Suppositories

BioPure
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Probiotics in a suppository bypass digestion, support digestive & immune health

$200.00

Bravo Europe Probiotic Suppositories serve as an innovative and efficient means to deliver a combination of beneficial, live probiotic strains, whole healthful colostrum, and healing emollients, directly to the lower end of the intestinal tract.

Research during the last few decades has proven that the intestine is not just a one-way highway to elimination. It contains a rich supply of blood vessels that actively exchange substances, and mucous membranes that harbor vast communities of functional bacteria. A proper balance of microbiota in the gut can support healthy immune function and can even support central nervous system function and mood*. The intestine lubricates and facilitates passage of stool, and can also absorb and deliver nutrients, enzymes, medicines, and other herbal substances to and from the circulatory system. In some cases, a substance can be more efficiently absorbed or utilized via targeted rectal delivery than when taken orally, because it bypasses digestion by the strong acids, enzymes, and bile in the stomach, small intestines, and liver. There are also times when oral administration of probiotics may not be possible, for instance, if a patient is incapable of swallowing because they are nauseous, unconscious, or uncooperative–as in the case of a small child.

Numerous studies have examined the complex mechanisms by which the beneficial effects of probiotics occur. Bacteria help create a protective lining on the walls of the intestine by stimulating the production of mucus and regulating adherence by certain bacteria. Antimicrobial peptides, or bacteriocins, are produced by these bacteria and establish competitive exclusion of pathogenic strains.

Bravo Europe Probiotic Suppositories contain a combination of high quality, organic, freeze dried colostrum, fermented with a proprietary blend of probiotic bacteria made in Switzerland. The bacterial strains are commonly used in Europe and the US for making yogurt and kefir. Colostrum is the first milk produced after giving birth, and is especially important for development of the infant immune system, because it is a source of immunoglobulins, antibodies, antimicrobial peptides, growth factors, and other bioactive molecules. Experiments with dogs fed bovine colostrum showed an increase in the diversity and stability of gut microbiota, as well as immune response. The stability, beneficial properties, and synergistic bioactivity of whole, naturally derived colostrum, offers potential advantages over isolated extracts.

The potent probiotics and healthful milk products are molded into sleek, convenient suppositories with creamy cocoa butter. BioPure’s cocoa butter is 100% organic, undeodorized, unbleached, and naturally contains vitamins, minerals, and bioflavonoids with antioxidant properties. Cocoa butter has been used for centuries to soothe and moisturize the skin and support wound healing. It is stable and solid at room temperature, but melts easily in the body.

References:

Amit-Romach E, Uni Z, Friedman M, Aizenberg I, Berkovich Z, Reifen R. A new mode of probiotic therapy: Specific targeting. Journal of Functional Foods. June 2015, Vol 16:386-392.

Bendali F, Madi N, Sadoun D. Beneficial effects of a strain of Lactobacillus paracasei subsp. paracasei in Staphylococcus aureus-induced intestinal and colonic injury. International Journal of Infectious Diseases 15 (2011) 787–794.

Bermudez-Brito M, Plaza-Diaz, J, Muñoz-Quezada S, Gómez-Llorente C, Gil A. Probiotic Mechanisms of Action. Annals of Nutrition and Metabolism. 2012;61:160-174.

Daliri E B-M and Lee BH. New Perspectives on Probiotics in Health and Disease. Food Science and Human Wellness. 2015 (4):56-65.

Dobson A, Cotter PD, Ross RP Hill C. Bacteriocin production: a probiotic trait? Appl Environ Microbiol. 2012. Jan;78(1):1-6.

Forrest BD, Shearman DJC, LaBrooy JT. Specific immune response in humans following rectal delivery of live typhoid vaccine. Vaccine. June 1990, Vol 8, Issue 3:209-212.

Hawrelak JA, Myers SP. The causes of intestinal dysbiosis: a review. Altern Med Rev. 2004 Jun;9(2):180-97.

Katz DL, Doughty K, and Ali A. Cocoa and chocolate in human health and disease. Antioxidants & Redox Signaling. Nov 15, 2011, 15(10): 2779-2811.

Konturek PC, Brzozowski T, Konturek SJ. Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options. J Physiol Pharmacol. 2011 Dec;62(6):591-9.

Lamuela-Raventós RM et al. Review: Health Effects of Cocoa Flavonoids. Food Science and Technology International. June 2005 Vol. 11 no. 3 159-176.

Picard C, Fioramonti J, Francois A, Robinson T, Neant F, Matuchansky C. Review article: Bifidobacteria as probiotic agents — physiological effects and clinical benefits. Aliment Pharmacol Ther. 2005 Sep 15; 22(6):495-512.

Satyaraj E, Reynolds A, Pelker R, Labuda J, Zhang P, Sun P. Supplementation of diets with bovine colostrum influences immune function in dogs. British Journal of Nutrition. December 2013. Vol 110; Issue 12. Pp 2216-2221.

Sekirov I, Russell SL, Antunes CM, and Finlay BB. Gut Microbiota in Health and Disease. Physiol Rev. July 1, 2010 vol. 90 no. 3 859-904.

Upreti, RK, Richa S, Chaturvedi UC. Gut microflora & toxic metals: chromium as a model. Indian Journal of Medical Research. 2004, 119. pp. 49-59.

Yan F, Polk DB. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J Biol Chem. 2002 Dec 27;277(52):50959-65.

The full list of microorganisms of the starter used for the fermentation of Bravo is the following:

Lactobacillus bulgaricus
Streptococcus thermophilus
Bifidobacterium infantis
Bifidobacterium bifidum
Bifidobacterium lactis
Bifidobacterium longum

Kefir grains

At the end of the freeze drying process a blend of eight strains of freeze dried gastro-resistant bacteria is added to the product:

Lactobacillus salivarius
Lactobacillus paracasei
Lactobacillus acidophilus
Lactobacillus rhamnosus
Lactococcus lactis
Bifidobacterium infantis
Bifidobacterium bifidum
Bifidobacterium lactis

Please notice that: None of the above listed microorganisms is considered to be pathogenic for livestock or poultry and all are considered safe for human consumption.

The product contains cow’s milk and cow’s colostrum.

The product is produced without the use of bioengineering.

Contains no: sugar, salt, starch, yeast, wheat, gluten, corn, egg, shellfish, artificial colors, artificial flavors, preservatives, synthetic growth hormones.