Bravo Suppositories are an innovative and efficient means that provide a combination of beneficial, live probiotic strains, whole healthful colostrum, and emollients.
Research during the last few decades has proven that the intestine is not just a one-way highway to elimination. It contains a rich supply of blood vessels that actively exchange substances, and mucous membranes that harbor vast communities of functional bacteria. The large intestine lubricates and facilitates passage of stools, and can also harbor a nutrient-rich colon environment, which is essential to a proper functioning circulatory system. In some cases, a substance can be more efficiently delivered into the body rectally. Bravo Suppositories are optimally designed for fast delivery and activity once administered.
Numerous studies have examined the complex mechanisms by which the beneficial effects of probiotics occur. Bacteria help create a protective lining on the walls of the intestine by stimulating the production of mucus and regulating adherence by certain bacteria. Antimicrobial peptides, or bacteriocins, are produced by these bacteria and establish competitive exclusion of pathogenic strains.
Bravo Europe Probiotic Suppositories contain a combination of high quality, organic, freeze dried colostrum, fermented with a proprietary blend of probiotic bacteria made in Switzerland. The bacterial strains are commonly used in Europe and the US for making yogurt and kefir. Colostrum is the first milk produced after giving birth, and is especially important for development of the infant immune system, because it is a source of immunoglobulins, antibodies, antimicrobial peptides, and other bioactive molecules. Experiments with dogs fed bovine colostrum showed an increase in the diversity and stability of gut microbiota, as well as immune response. The stability, beneficial properties, and synergistic bioactivity of whole, naturally derived colostrum, offers potential advantages over isolated extracts.
The potent probiotics and healthful milk products are molded into sleek, convenient suppositories with creamy cocoa butter. BioPure’s cocoa butter is 100% organic, undeodorized, unbleached, and naturally contains vitamins, minerals, and bioflavonoids with antioxidant properties. Cocoa butter has been used for centuries to soothe and moisturize the skin and support wound healing. It is stable and solid at room temperature, but melts easily in the body.
The full list of microorganisms of the starter used for the fermentation of Bravo is the following:
At the end of the freeze drying process a blend of eight strains of freeze dried gastro-resistant bacteria is added to the product:
Please notice that: None of the above listed microorganisms are considered to be pathogenic for livestock or poultry.The product contains cow’s milk and cow’s colostrum.
The product is produced without the use of bioengineering.
Bendali F, Madi N, Sadoun D. Beneficial effects of a strain of Lactobacillus paracasei subsp. paracasei in Staphylococcus aureus-induced intestinal and colonic injury. International Journal of Infectious Diseases 15 (2011) 787–794.
Bermudez-Brito M, Plaza-Diaz, J, Muñoz-Quezada S, Gómez-Llorente C, Gil A. Probiotic Mechanisms of Action. Annals of Nutrition and Metabolism. 2012;61:160-174.
Daliri E B-M and Lee BH. New Perspectives on Probiotics in Health and Disease. Food Science and Human Wellness. 2015 (4):56-65.
Dobson A, Cotter PD, Ross RP Hill C. Bacteriocin production: a probiotic trait? Appl Environ Microbiol. 2012. Jan;78(1):1-6.
Hawrelak JA, Myers SP. The causes of intestinal dysbiosis: a review. Altern Med Rev. 2004 Jun;9(2):180-97.
Katz DL, Doughty K, and Ali A. Cocoa and chocolate in human health and disease. Antioxidants & Redox Signaling. Nov 15, 2011, 15(10): 2779-2811.
Lamuela-Raventós RM et al. Review: Health Effects of Cocoa Flavonoids. Food Science and Technology International. June 2005 Vol. 11 no. 3 159-176.
Picard C, Fioramonti J, Francois A, Robinson T, Neant F, Matuchansky C. Review article: Bifidobacteria as probiotic agents — physiological effects and clinical benefits. Aliment Pharmacol Ther. 2005 Sep 15; 22(6):495-512.
Satyaraj E, Reynolds A, Pelker R, Labuda J, Zhang P, Sun P. Supplementation of diets with bovine colostrum influences immune function in dogs. British Journal of Nutrition. December 2013. Vol 110; Issue 12. Pp 2216-2221.
Sekirov I, Russell SL, Antunes CM, and Finlay BB. Gut Microbiota in Health and Disease. Physiol Rev. July 1, 2010 vol. 90 no. 3 859-904.
Upreti, RK, Richa S, Chaturvedi UC. Gut microflora & toxic metals: chromium as a model. Indian Journal of Medical Research. 2004, 119. pp. 49-59.
Yan F, Polk DB. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J Biol Chem. 2002 Dec 27;277(52):50959-65.