Key Five

Synergistic blend of Cilantro, Ginkgo, Lemon Balm, Biscuitroot & St. John's Wort

BioPure Key Five


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BioPure Key Five TM Herbal Tincture

A synergistic blend of Cilantro (Coriandrum sativum), Ginkgo (Ginkgo biloba), Lemon Balm (Melissa officinalis), Biscuit root (Lomatium dissectum), and St. John’s Wort (Hypericum perforatum). Key Five condenses BioPure Viressence tincture down to five ingredients that help bolster the body’s immune system, cleanse, and support the nervous system.*

Compare the benefits of our Viressence, Key Five & Vital Four herbal tinctures:
See Research & More Information below to learn more about BioPure’s Vital Four Herbal Tincture.


Research & More Information

Lemon balm is uniquely harmonizing in its effect on the human body. It can be used to calm anxious feelings, improve cognitive function, and uplift mood.*

St. John’s Wort may be helpful in relieving conditions of premenstrual syndrome and menopause.

Lomatium (Biscuit root) is another Pacific Northwest native plant that was used by local Indian tribes for a variety of health benefits.

Ginkgo biloba is most well known for its ability to support healthy blood flow and enhance cognitive ability and memory.* It is a source of two important classes of antioxidants: flavonoids and terpenoids.

Cilantro, the well-known culinary herb, contributes to the support of the immune system in large measure due to its antioxidant properties.


Kennedy DO, Wake G, Savelev S, Tildesley NTJ, Perry EK, Wesnes KA and ScholeyAB. Modulation of Mood and Cognitive Performance Following Acute Administration of Single Doses of Melissa officinalis (Lemon Balm) with Human CNS Nicotinic and Muscarinic Receptor-Binding Properties. Neuropsychopharmacology (2003) 28, 1871–1881.

Víctor López, Sara Martín, Maria Pilar Gómez-Serranillos, Maria Emilia Carretero, Anna K. Jäger and Maria Isabel Calvo. Neuroprotective and Neurological Properties of Melissa officinalisNeurochemical Research. Volume 34, Number 11 (2009), 1955-1961.

Savino F, Cresi F, Castagno E, Silvestro L, Oggero R. A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare and Melissa officinalis (ColiMil®) in the treatment of breastfed colicky infants. Phytotherapy Research. Volume 19, Issue 4, pages 335–340, April 2005.

Hăncianu M, Aprotosoaie AC, Gille E, Poiată A, Tuchiluş C, Spac A, Stănescu U. Chemical composition and in vitro antimicrobial activity of essential oil of Melissa officinalis L. from Romania. Rev Med Chir Soc Med Nat Iasi. 2008 Jul-Sep;112(3):843-7.

Whiskey E, Werneke U, Taylor D. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review. Int Clin Psychopharmacol. 2001 Sep;16(5):239-52.

Mischoulon D. Update and critique of natural remedies as antidepressant treatments. Psychiatr Clin North Am. 2007 Mar;30(1):51-68.

Martinez B, Kasper S, Ruhrmann S, Möller H-J. Hypericum in the Treatment of Seasonal Affective Disorders. J Geriatr Psychiatry Neurol. October 1994 vol. 7 no. 1 S29-S33.

Harrer G. Hypericum and phototherapy. Praxis (Bern 1994). 2000 Dec 14;89(50):2123-9.

Kumar V, Mdzinarishvili A, Kiewert C, Abbruscato T, Bickel U, van der Schyf CJ, and Klein J. NMDA Receptor-Antagonistic Properties of Hyperforin, a Constituent of St. John’s Wort. J Pharmacol Sci 102, 47 – 54 (2006)

Barnes J, Anderson LA, Phillipson JD. St John’s wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J Pharm Pharmacol. 2001 May;53(5):583-600.

Bergner, P. Antiviral Botanicals in Herbal Medicine. Medical Herbalism (Spring 2005)14(3):1-12.

Kennedy DO and Wightman EL. Herbal Extracts and Phytochemicals: Plant Secondary Metabolites and the Enhancement of Human Brain Function. Adv. Nutr. 2: 32–50, 2011.

Kleijnen J, Knipschild P. Ginkgo biloba for cerebral insufficiency. British Journal of Clinical Pharmacology. Volume 34, Issue 4, pages 352–358, Oct 1992.

Nishida S, Satoh H. Comparative vasodilating actions among terpenoids and flavonoids contained in Ginkgo biloba extract. Clin Chim Acta. 2004 Jan;339(1-2):129-33.

Muir AH, Robb R, McLaren M, Daly F, Belch JJ. The use of Ginkgo biloba in Raynaud’s disease: a double-blind placebo-controlled trial. Vasc Med. 2002;7(4):265-7.

Wong PYY, Kitts DD. Studies on the dual antioxidant and antibacterial properties of parsley (Petroselinum crispum) and cilantro (Coriandrum sativum) extracts. Food Chemistry. Volume 97, Issue 3, August 2006, Pages 505–515.

L Joji Reddy, Reshma Devi Jalli, Beena Jose, Spandana Gopu. Evaluation of antibacterial and DPPH radical scavenging activities of the leaf extracts and leaf essential oil of Coriandrum sativumWorld Journal of Pharmaceutical Research 2012. Vol 1, Issue 3, 705-716.

Deepa B, Anuradha CV. Antioxidant potential of Coriandrum sativum L. seed extract. Indian J Exp Biol. 2011 Jan;49(1):30-8.

M.S. Hashim, S. Lincy, V. Remya, M. Teena and L. Anila. Effect of polyphenolic compounds from Coriandrum sativum on H2O2-induced oxidative stress in human lymphocytes. Food Chemistry Volume 92, Issue 4, October 2005, Pages 653-660.

Gray AM and Flatt PR. Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander). British Journal of Nutrition / Volume 81 / Issue 3 / March 1999, pp 203-209.