Japanese Knotweed

BioPure Japanese Knotweed

Tincture concentrates resveratrol for antioxidant & immune system support


SKU: 543 Category:

BioPure Japanese Knotweed from Polygonum cuspidatum, also known as Japanese Knotweed, or by the Mandarin Chinese name of Hu Zhang, is native to Asia, and is a robust perennial in the Buckwheat family. It tends to grow in thickets, has upright racemes of creamy white flowers, large oval to heart-shaped leaves, and chunky, hollow, stems that resemble bamboo. It is sometimes sold under the alternative names of Fallopia japonica or Reynoutria japonica.

In traditional Chinese medicine, BioPure Japanese Knotweed is described as bitter and slightly cold, and its uses include supporting the body’s natural detoxification pathways, increasing blood circulation, clearing heat, for various skin concerns, menstruation support, improving liver and cardiovascular health, and as a diuretic.*

Japanese Knotweed extract has demonstrated comprehensive effects on reducing oxidative stress through several complex mechanisms.* The plant contains three main classes of bioactive chemicals; anthroquinones, flavonoids, and stilbenes. The stilbene, Resveratrol, is perhaps the most well-known compound found in Knotweed and is responsible for most of the health benefits associated with this plant. Although Resveratrol gained most of its notoriety after being identified in grape skins and red wine, other sources include blueberries, cranberries, peanuts, pistachios, and soy. Most commercial production of resveratrol for nutritional supplements and scientific experimentation is extracted from the dried roots of Polygonum cuspidatum. Resveratrol has been shown to be a powerful antioxidant. Its beneficial health effects support the cardiovascular and nervous systems, as well as blood sugar, weight and aging processes.* Resveratrol has also demonstrated a protective effect for the kidneys.*

Some of the lesser known bioactive constituents of Knotweed include the anthroquinones, emodin and citreorosein. Another stilbene in Knotweed, known as polydatin, has shown many promising aspects including neurological support for the brain and heart, contribution to cardiovascular health by improving the serum lipid profile, and protection of mice livers from CCl4-induced injury.*

Although Japanese Knotweed has significant health-promoting properties, it is also considered one of the world’s most invasive plants.* It vigorously spreads along roadsides, streambanks, and areas disturbed by development. It creates extensive root systems and easily smothers and crowds out other species. In many areas of the United States, it is listed as a “Noxious Weed” requiring strict control. For this reason, BioPure highly recommends that people wanting to utilize the plants healthful benefits obtain extracts from plants grown under controlled conditions, such as ours. Other products carried by BioPure that contain Polygonum cuspidatum are Quintessence and BioPure’s Cocktail.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.



Albertoni G, Schor N. Resveratrol plays important role in protective mechanisms in renal disease–mini-review. J Bras Nefrol. 2015 Jan-Mar;37(1):106-14.

Braidy N, Jugder BE, Poljak A, Jayasena T, Mansour H, Nabavi SM, Sachdev P, Grant R. Resveratrol as a Potential Therapeutic Candidate for the Treatment and Management of Alzheimer’s Disease. Curr Top Med Chem. 2016;16(17):1951-60.

Burns J, Yokota T, Ashihara H, Lean ME, Crozier A. Plant foods and herbal sources of resveratrol. J Agric Food Chem. 2002 May 22;50(11):3337-40.

Gao JP, Chen CX, Gu WL, Wu Q, Wang Y, Lu J. Effects of polydatin on attenuating ventricular remodeling in isoproterenol-induced mouse and pressure-overload rat models. Fitoterapia. Volume 81, Issue 7, October 2010, Pages 953–960.

Ghanim H, Sia CL, Abuaysheh S, Korzeniewski K, Patnaik P, Marumganti A, Chaudhuri A, Dandona P. An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J Clin Endocrinol Metab. 2010 Sep;95(9):E1-8.


Hung LM, Chen JK, Huang SS, Lee RS, Su MJ. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc Res. 2000 Aug 18;47(3):549-55.

Petrovski G, Gurasamy N, Das DK. Resveratrol in cardiovascular health and disease. Ann. N.Y. Acad. Sci. 1215 (2011) 22–33.

Wang S, Zheng Z, Weng Y, Yu Y, Zhang D, Fan W, Dai R, Hu Z. Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts. Life Sci. 2004 Apr 2;74(20):2467-78.

Zhang H, Li C, Kwok ST, Zhang QW, Chan SW. A Review of the Pharmacological Effects of the Dried Root of Polygonum cuspidatum (Hu Zhang) and Its Constituents. Evidence-Based Complementary and Alternative Medicine. Volume 2013, Article ID 208349, 13 pages.

Zhang H, Yu CH, Jiang YP, Peng C, He K, Tang JY, Xin HL. Protective Effects of Polydatin from Polygonum cuspidatum against Carbon Tetrachloride-Induced Liver Injury in Mice. PLoS One. 2012; 7(9): e46574.