BioPure Core™ is comprised of highly bioavailable forms of 5 minerals, 2 vitamins, and an amino acid, in a unique formulation combined to support core aspects of human health, including the immune system.*
With the exception of calcium that forms a major part of our bone structure, most of the minerals in the human body are present in relatively small amounts, but their importance to human health cannot be overstated. The trace minerals in BioPure Core™play critical roles as cofactors in a myriad of enzymatic pathways.* Although most minerals are available in foods we eat, deficiencies can occur from a number of causes including environmental factors, injury recovery, genetics, stress, medications, overexertion, athletes demanding high performance, aging, diets, bacterial infections, and lifestyle differences. BioPure Core™ is an additional source of important trace minerals and other nutrients.
The following nutrients are present in Core™:
Vitamin B6 (19 mg), also known as Pyridoxine, is one of eight water-soluble vitamins in the B complex. It serves as a cofactor in nearly 100 enzymatic reactions within the human body.* Vitamin B6 is critical in the production of amino acids and in obtaining energy from the food we eat, and it supports heart health.*
Biotin (2,000 mcg), also a member of the B complex and sometimes referred to as Vitamin H, is an essential micronutrient for all mammals. As a coenzyme, Biotin plays key roles in the breakdown of fats, carbohydrates, and proteins.* It supports skin, hair, and nail health, normal blood sugar metabolism, and proper neurological function, and is particularly important during pregnancy for proper fetal development.*
Zinc (10 mg) is an essential trace mineral, and is ubiquitous within cells throughout the body. The numerous roles played by zinc in human metabolism include catalytic, structural, and regulatory functions.* It supports the immune system, eyesight, neurological function, and growth and development at all ages–especially prenatally and during infancy.* The zinc in Core™ is bound to monomethionine, glycinate, gluconate, and picolinate. Zinc is made more absorbable and bioavailable when complexed with these organic compounds.*
Manganese (1.8 mg) is a mineral component of manganese super oxide dismutase (MnSOD), which is a powerful antioxidant enzyme found in human mitochondria. MnSOD helps support healthy cell membranes and DNA by scavenging free radical oxygen.* Manganese is essential for bone health, production of collagen, and proper metabolism of fats, carbohydrates, and amino acids.*
Chromium (125 mcg) is involved in thyroid metabolism, RNA synthesis and protein metabolism.* The chromium in Core™ is chemically bound with the amino acid glycine and it is safe and highly bioavailable.
Molybdenum (100 mcg) is a mineral needed in the human body in small amounts to form compounds with organic molecules and enzymes that affect numerous processes including protein synthesis, iron uptake, detoxification, and elimination of wastes.* Some people use molybdenum to help support dental health.* In Core™, molybdenum is bound to the amino acid glycine, facilitating its absorption and bioavailablity.
Magnesium (2.5 mg) is one of the most plentiful minerals in the human body, playing key roles in hundreds of enzymatic reactions and metabolic functions.* It helps regulate cell membrane transport, supports healthy bones and teeth, facilitates muscle contraction, supports cardiovascular health, aids in energy production, is part of DNA and RNA synthesis, and more.* Chelated to the amino acid glycine, magnesium bisglycinate in Core™ provides the highest level of absorption, bioavailability, and safety.
Boron as citrate chelate and amino acid complex (1mg) is involved in many bodily functions, including the metabolism of calcium, magnesium, and vitamin D, supporting healthy bone growth and joint movement, and in the regulation of thyroid and sex hormones.* Although not yet considered essential, there is growing evidence of the importance of this trace mineral.
L-Taurine (21mg) is an amino acid important for heart function, vasodilation, and as an antioxidant.* Taurine also supports a healthy digestive system, and retinal development and function.*
Other ingredients in BioPure Core present in small amounts are silica, cellulose, and ascorbyl palmitate. Silica, also known as silicon dioxide, is a naturally occurring substance that the human body needs a very small amount of for healthy bones, collagen, and cartilage.* In Core™, silica serves the dual purpose of acting as a flow agent. The capsules are made with a small amount of non-digestible cellulose, providing a vegetarian alternative to animal-sourced gelatin capsules. Ascorbyl palmitate is a fat-soluble antioxidant that contributes an insignificant amount of Vitamin C, and primarily serves the purpose of protecting and extending the shelf-life of all the fat-soluble antioxidants in the supplement.
Core™ can help ensure the body has an adequate supply of manganese and other important minerals.*
Aguirre JD1, Clark HM, McIlvin M, Vazquez C, Palmere SL, Grab DJ, Seshu J, Hart PJ, Saito M, Culotta VC. A manganese-rich environment supports superoxide dismutase activity in a Lyme disease pathogen, Borrelia burgdorferi. J Biol Chem. 2013 Mar 22;288(12):8468-78.
Aschner JL and Aschner M. Nutritional aspects of manganese homeostasis. Molecular Aspects of Medicine 26 (2005) 353–362.
Barrie SA, Wright JV, Pizzorno JE, Kutter E, Barron PC. Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans. Agents Actions. 1987 Jun;21(1-2):223-8.
Cefalu WT and Hu FB. Role of Chromium in Human Health and in Diabetes. Diabetes Care. November 2004 vol. 27 no. 11 2741-2751.
Coughlan MP. The role of molybdenum in human biology. Journal of Inherited Metabolic Disease 1983, Volume 6, Issue 1 Supplement, pp 70-77.
Dinca L and Scorei R. Boron in Human Nutrition and its Regulations Use. Journal of Nutritional Therapeutics, 2013, 2, 22-29.
Huskisson E, Maggini S, and Ruf M. The Role of Vitamins and Minerals in Energy Metabolism and Well-Being. The Journal of International Medical Research 2007; 35: 277-289.
Juttukonda LJ, Skaar EP. Manganese homeostasis and utilization in pathogenic bacteria. Mol Microbiol. 2015 Jul;97(2):216-28.
Krejpcio Z. Essentiality of Chromium for Human Nutrition and Health. Polish Journal of Environmental Studies Vol. 10, No. 6 (2001), 399-404.
Lamson D and Plaza S. The Safety and Efficacy of High-Dose Chromium. Alternative Medicine Review. Vol 7 No 3; 2002. Pg 218-235.
Li C and Shou HM. The Role of Manganese Superoxide Dismutase in Inflammation Defense. Enzyme Research. Vol. 2011. Article ID 387176.
Lisher JP and Giedroc DP. Manganese acquisition and homeostasis at the host-pathogen interface. Frontiers in Cellular and Infection Microbiology, 05 December 2013.
Lourenço R, Camilo ME. Taurine: a conditionally essential amino acid in humans? An overview in health and disease. Nutr Hosp. 2002 Nov-Dec;17(6):262-70.
Martin KR. The chemistry of silica and its potential health benefits. J Nutr Health Aging. 2007 Mar-Apr;11(2):94-7.
Miroff G, Mowles R, Pangborn JB, Philpott WH, Molybdenum for Candida albicans Patients and Other Problems. The Digest of Chiropractic Economics Jan-Feb 1991, 31:4 pp 56-63.
Mock DM. Adequate Intake of Biotin in Pregnancy: Why Bother? J Nutr. 2014 Dec; 144(12): 1885-1886.
Muszyńska A, Pałka J, Gorodkiewicz E. The mechanism of daunorubicin-induced inhibition of prolidase activity in human skin fibroblasts and its implication to impaired collagen biosynthesis. Exp Toxicol Pathol. 2000 May;52(2):149-55.
Newnham RE. Essentiality of boron for healthy bones and joints. Environ Health Perspect. 1994 Nov;102 Suppl 7:83-5.
Nielsen FH and Meacham SL. Growing Evidence for Human Health Benefits of Boron. Journal of Evidence-Based Complementary & Alternative Medicine. October 2011 vol. 16 no. 3 169-180.
Posey JE, Gherardini FC. Lack of a role for iron in the Lyme disease pathogen. Science. 2000 Jun 2;288(5471):1651-3.
Prasad AS. Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease. Adv. Nutr. 4: 176–190, 2013.
Rodriguez MR. Importance of biotin metabolism. Rev Invest Clin. 2000 Mar-Apr;52(2):194-9.
Roohani N, Hurrell R, Kelishadi R, Schulin R. J Res Med Sci. 2013 Feb; 18(2): 144-157.
Said HM. Biotin: the forgotten vitamin. Am J Clin Nutr. February 2002 vol. 75 no. 2 179-180.
Schlegel P, Windisch W. Bioavailability of zinc glycinate in comparison with zinc sulphate in the presence of dietary phytate in an animal model with Zn labelled rats. J Anim Physiol Anim Nutr (Berl). 2006 Jun;90(5-6):216-22.
Seibrecht S. Magnesium Bisglycinate as safe form for mineral supplementation in human nutrition. OM & Ernährung 2013. Nr. 144. 16 pgs.
Skaar EP. The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts. PLoS Pathog. 2010 Aug; 6(8).
Soetan KO, Olaiya CO and Oyewole OE. The importance of mineral elements for humans, domestic animals and plants: A review. African Journal of Food Science Vol. 4(5) pp. 200-222, May 2010
Suidasari S, Hasegawa T, Yanaka N and Kato N. Dietary supplemental vitamin B6 increases carnosine and anserine concentrations in the heart of rats. Springerplus, 2015 Jun 19;4:290.
Xu YJ, Arneja AS, Tappia PS, and Dhalla NS. The potential health benefits of taurine in cardiovascular disease. Exp Clin Cardiol. 2008 Summer Vol 13(2):57-65.