Liposomal Melatonin Phospholipid

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BioPure’s Liposomal Melatonin is primarily used to support normal sleep patterns and cognitive function.*

Melatonin is a hormone produced mainly in the pineal gland of the brain during the nighttime hours. It is involved with regulating the sleep-wake cycle in humans as well as circadian rhythms throughout the animal kingdom. Darkness stimulates the pineal gland to produce melatonin and light inhibits it. Natural melatonin, and the synthetic forms that are being developed, have hypnotic and sleep-promoting actions, without hangover, withdrawal, or other side effects, and they are proving to be a useful supplemental support. The mechanism by which melatonin promotes sleep appears to be largely due to its effect on specific receptors in the hypothalamus “sleep switch”. Experiments with humans, monkeys, cats, and other animals have shown that melatonin can support normal sleep quality and duration.*


Secretion of melatonin decreases with age, which may result in less efficient sleep patterns that are common among older adults. The importance of sleep as a time when our body rejuvenates, repairs, and detoxifies is well established. During sleep there is a significant exchange of cerebrospinal and interstitial fluid. Neurotoxic metabolic waste is cleared away, and important bioactive compounds such as amino acids, glucose, and lipids are distributed. Circulation of melatonin also increases at this time, allowing it to do its important radical scavenging and antioxidant processes. This maintenance by the brain’s glymphatic drainage system could be compared to “taking out the trash” and organizing the cupboards for better functioning.

Jet Lag Disorder can happen when circadian rhythms are disrupted as a result of quickly traveling across several time zones, rotating shift work, or poor vision. Symptoms include insomnia, fatigue, reduced alertness and cognitive skills, and loss of appetite. Melatonin supplementation, especially when combined with timed light exposure and exercise, has been found to be very helpful.*

As more research studies are done involving melatonin and its synthetic derivatives, we are learning that this indoleamine molecule is synthesized in other tissues and organs besides the pineal gland, stimulated by means other than darkness, and that it affects far more than just sleep. Melatonin is referred to as “pleiotropic” because it has multiple effects on seemingly unrelated events as diverse as regulating protein synthesis and mitochondrial biogenesis, exerting antioxidant reactions, affecting insulin resistance and weight, and slowing neurodegenerative diseases. It also has an important role in immunoregulation, oral health, bone formation, and eyesight, and may be linked to supporting proper gastrointestinal physiology and oxygen supply levels in brain tissue.

One pump of BioPure’s Liposomal Melatonin spray into the mouth contains 4mg of synthetic melatonin encapsulated within tiny packages, or liposomes, made from purified natural sunflower lecithin phospholipids. This method of delivery has several advantages. The bioavailability of the contents is increased by an affinity with the phospholipids in our own cell membranes. The phospholipids can have a strong synergistic effect, creating a “push” or boost of the beneficial effects of the contents. The richly vascularized mucosa of the mouth and throat encourages rapid absorption. The liposomal contents are protected against early inactivation, degradation, and dilution in the circulation, as well as breakdown by the enzymes and high acidity of the gastrointestinal tract. Sunflower lecithin is used to avoid soy allergies. BioPure’s Liposomal Melatonin is suspended in a solution of water, ethanol, glycerin, Vitamin E, and medium-chain triglycerides.


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